Abstract: Machine translation has many applications such as news translation, email translation, official letter translation etc. Commercial translators, e.g. Google Translation lags in regional vocabulary and are unable to learn the bilingual text in the source and target languages within the input. In this paper, a regional vocabulary-based application-oriented Neural Machine Translation (NMT) model is proposed over the data set of emails used at the University for communication over a period of three years. A state-of-the-art Sequence-to-Sequence Neural Network for ML → EN (Malay to English) and EN → ML (English to Malay) translations is compared with Google Translate using Gated Recurrent Unit Recurrent Neural Network machine translation model with attention decoder. The low BLEU score of Google Translation in comparison to our model indicates that the application based regional models are better. The low BLEU score of English to Malay of our model and Google Translation indicates that the Malay Language has complex language features corresponding to English.